Our Work

At the Vivante Lab, we are committed to advancing the understanding of the genetic and molecular basis of chronic kidney disease (CKD) to enable earlier diagnosis, improve risk prediction, and ultimately develop targeted gene-based therapies for patients.

Our research spans the full spectrum of translational nephrogenetics—from gene discovery to therapy. We combine comprehensive genomic analysis with functional studies of novel disease-causing genes, and actively pursue the development of precision treatments based on molecular insights.

A cornerstone of our work is the Israeli Kidney Failure Genetic Cohort, a nationwide miltuethnic initiative established by our team. This unique resource includes over 3,000 individuals recruited from more than 50 dialysis units across Israel, representing a wide range of ethnic backgrounds and clinical phenotypes.

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We also collaborate closely with the National Nephrogenetic Clinic at Sheba Medical Center, led by Prof. Asaf Vivante. The clinic serves as Israel’s central referral center for genetic kidney diseases diagnosis, monitoring and treatment.

By integrating next-generation sequencing, cellular and animal models, and innovative therapeutic platforms, the Vivante Lab is positioned at the forefront of translational kidney genetics research. Our goal is to bridge the gap between rare disease discovery and clinical implementation, while fostering collaboration and training the next generation of physician-scientists and geneticists.